Pretty simple and as described in the title.
If I have Amazon Prime you can obviously track my viewing history, and use it to NOT show me ads for the shows I have seen.

Currently I get about 4 rotating ads (Cloak & Dagger, Hanna, Grand Tour, Jack Ryan).
Three of these I've already seen, and so whenever I get an ad for them now I just close out the Twitch desktop client and restart it - because that's faster and less annoying than watching the ad to completion.

So maybe you could tone down the ads, or at the very least don't show us the ads that 100% ARE OF NO INTEREST TO US BECAUSE WE ALREADY BOUGHT INTO/WATCHED YOUR PRODUCT.